Phenobarbital



- for seizure disorders, insomnia, anxiety;
- Adult: sedative- hypnotic: 30-120mg PO or IM qd prn;
- Anticonvulsant:loading dose:10-12 mg/kg in 3 divided doses, then 1-3 mg/kg/24 hr;
- Note tolerance will develop to sedation;
- paradoxical hyperactivity seen in pediatric patients; long half life allows single daily dose; therapeutic dose: 15-40; >45=toxic;
Contraindications: Respiratory disease with the presence of dyspnea or obstruction; Use with caution in patients cardiovascular, pulmonary, hepatic, or renal disease; Must reduce dose w/ liver impairment;
- Peds: Sedative: 1-2 mg/kg/24hr PO or PR in 3 DD; Hypnotic: 2-4 mg/kg/24hr
    PO or PR qhs prn;
    Anticonvulsant: 3-5 mg/kg/24hr PO divided into 2-3 doses following a loading dose o 15-20 mg/kg divided into 2 equal doses 4 hours apart;
- Tab: 15, 30, 60 mg



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Tuesday, July 31, 2012 1:54 pm