Phenelzine/Nardil



Phenelzine is a MAOI;
DOSING INFORMATION:  Recommended oral adult doses of phenelzine are 45 to 75 mg/day; alternatively,
- Onset of activity is noted within 2 weeks, however, maximal effects are not seen until up to 6 weeks of therapy.
    - Phenelzine is well absorbed following oral administration and is excreted primarily as metabolites in the urine.
- Phenelzine should be used cautiously in combination w/ tricyclic antidepressants or other MAO inhibitors; foods with a high tyramine content should be avoided.
- Frequent adverse effects of phenelzine include orthostatic hypotension, drowsiness, dizziness, mania, agitation, and weight gain.
- anticholinergic agents be avoided whenever possible;
- meperidine should definitely be avoided, whereas  fentanyl or morphine appear to be suitable during Hanesthesia;
- enflurane or isoflurane are preferred over halothane because of reduced arrhythmogenic potential;
- due to the possibility of hypotension associated with spinal and epidural anesthesia and the subsequent requirement for basopressors general anesthesia is preferred.



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Tuesday, July 3, 2012 2:41 pm