- Discussion:
- local failure of paraxial mesoderm to segment accounts for fused vertebrae;
-
Unilateral Bar:
- partial failure of segmentation laterally results in unsegmented bar formation;
- affected side of vertebra involved fails to grow, & growth of vertebrae on
side opposite bar may produce scoliosis;
-
congenital kyphosis:
- partial failure of segmentation anteriorly results in anterior fusion of
vertebral bodies;
- continued growth of the posterior portions of the partially fused vertebrae
result in kyphosis;
-
hemivertebrae:
- unilateral failure of formation of a sclerotome, failure of medial migration of
sclerotomal cells, or failure of differentiation of sclerotomal cells may
result in wedge-shaped
hemivertebra & scoliosis;
- Associated Conditions:
-
renal anomalies:
- relatively high incidence of renal anomalies is related to the fact that
kidney develops from mesoderm adjacent to
Somites;
-
pulmonary dysfunction;
- cor pulmonale
- back pain;
-
kyphosis may result in paralysis from stretched
spinal cord.
