Pamidronate

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- Discussion:
    - much more potent bisphosphonate than etidronate, has also proved to be effective therapy for hypercalcemia;
    - three different regimens have been used: slow IV infusion of 15-45 mg daily for upto 6 days;
    - single 24-hour IV infusion of up to 90 mg;

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References:

Efficacy of Pamidronate in Reducing Skeletal Complications in Patients with Breast Cancer and Lytic Bone Metastases.

Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases: long term follow-up of two randomized, placebo-controlled trials.

Zebra Lines of Pamidronate Therapy in Children