- See
Penicillin Family
* Adult: 4-12 gm q4-6hr; Peds ( > 4 yr): 150 mg/kg/24 hr;
* For
Staphlococcus; (
Penicillinase Res. Penicillin);
* Poorly absorbed orally,
cloxacillin or
dicloxacillin better for PO use;
* Intersitial nephritis can occur with high doses;
* Reduce dose in Renal failure;
- Dosing Regimens for Patients with RenalInsufficiency:
(Dose for 70 kg Adult {gm/dosing interval inhours}):
CrCl: >80:: 1/4-6;;CrCl:50-79::1/4-6;; CrCl:30-49:: 1/4-6;;
CrCl:10-29:: 1/4-6;;
- 20% of drug will be excreted in to urine (w/ nl RF(x))
- w/
osteomyelitis
Dose IV
time p admin.
Mean Ser conc (ug/ml)
Mean Bone conc (ug/gm)
1 gm
60 min.
18.9
2.1
2 gm
< 50
86.1
7.66
