Oxacillin





- See Penicillin Family

* Adult: 4-12 gm q4-6hr; Peds ( > 4 yr): 150 mg/kg/24 hr;
* For Staphlococcus; (Penicillinase Res. Penicillin);
* Poorly absorbed orally, cloxacillin or dicloxacillin better for PO use;
* Intersitial nephritis can occur with high doses;
* Reduce dose in Renal failure;
  - Dosing Regimens for Patients with RenalInsufficiency:
    (Dose for 70 kg Adult {gm/dosing interval inhours}):
    CrCl: >80:: 1/4-6;;CrCl:50-79::1/4-6;; CrCl:30-49:: 1/4-6;;
    CrCl:10-29:: 1/4-6;;
  - 20% of drug will be excreted in to urine (w/ nl RF(x))
- w/ osteomyelitis
  Dose IV   time p admin.   Mean Ser conc (ug/ml)     Mean Bone conc (ug/gm)
  1 gm         60 min.         18.9                     2.1
  2 gm       < 50               86.1                     7.66





Original Text by Clifford R. Wheeless, III, MD.