- for treatment of complicated and uncomplicated UTI due to a
    wide variety of pathogens including E. coli

Actinomyces israeli           Amp, PenG       Tetracycline clindamycin
Aeromonas hydrophilia         FQ Norflox     TMP/SMX
Bacteroides fragilis         Metronidazole clindamycin   cefoxitin
Borrelia burgdorferi         Ceftriaxone   Pen G         Erythromycin   Tetracycline
Enterobacter sp. cloacae,
    Proteus mirabilis, indole positive Proteus sp, P. aeruginosa,
    Staph aureus, Staphylococcus epidermidis;
- Quinolone antibiotic; inhibits DNA gyrase and inhibits all growth;
- Dosage: 400 mg PO bid 7-10 days (uncomplicated); 10-21 days (complicated);
- impaired renal function (CrCl < 30ml/min) reduce dose to 400mg PO qd;
- Not for use with pediatrics or pregnancy; must be taken 1hr AC or 2hr PC
    meals; do not take with antacids;
- Contra w/ hypersensitivity to quinolones;
- Dosing Regimensfor Patients with Renal Insufficiency: - Dose for 70kg
    Adult {gm/dosinginterval in hours}: CrCl:>80: 0.4/12;
    CrCl:50-79: 0.4/12; CrCl:30-49: 0.4/12; CrCl: 10-29: 0.4/24;
    - 30-40% of drug will be excreted in to urine (w/ nl RF(x))
- Norfloxacin will increase levels of Theophylline

Original Text by Clifford R. Wheeless, III, MD.