- Discussion:
-
NSAIA (member of the arylacetic acid group);
- for symptomatic RA, bone pain;
- primary dysmenorrhea, acute tendinitis and bursitis, mild to moderate pain:
- Adult:
- typical dose: 250 mg PO bid or 500 mg PO bid (500-1250 mg/24hr PO divided bid);
- available in 250, 375, or 500 mg capsules;
- Naprelan 375 or 500 mg: slow release form;
- for Acute Gout: Naprosyn 750mg PO initially, then 250mg PO q8h til attack has subsided;
- alternatively, try Anaprox 825mg initially then 275mg q8h til attack has subsided;
- Peds:
- Juvenile Rheumatoid arthritis: 10 mg/kg/24hrs PO to max dose of 1000
mg/24 hrs divided bid; supplied: tabs: 250mg, 375mg, 500mg;
- Precautions:
- aontraindicated: allergic reactions to ASA or
NSAIA;
- use with caution in patients with h/o of GI disease, impaired renal function, liver disease, CHF, elderly, diuretics;
- metabolized primarily in the liver to inactive metabolites;
- no dosage adjustment is required w/ renal insufficiency;
References for Naprosyn:
Naproxen prevention of heterotopic ossification after hip
arthroplasty. A prospective control study of 55 patients.
The clinical effect of naproxen sodium after arthroscopy of the knee: a
randomized, double-blind, prospective study.
