- See
Penicillin Family
- For penicillinase producing
Staph;
- Adult: 50-200 mg/kg/24hr;
IV: 500 mg - 1gm q4h for severe infections;
IM: 500 mg q4-6hr for severe infections;
PO: 250 - 500mg q4-6hr
- Peds: 100-200 mg/kg/day q6hr;
- Poorly absorbed orally,
cloxacillin or
dicloxacillin better for PO use;
- Note: Ratio of CSF to Blood Level (%): Normal Meninges: trace in 1/2
of pts.; Inflammed Meninges: 9-20;
- Cautions:
- can cause pain at IV site, and if subQ infiltration occurs, serious skin
sloughing may result;
- Requires Dose Reduction in Hepatic Dysfunction;
- Will interact with
aminoglycosides;
- Dosing Regimens for Patients w/ Renal Insufficiency:
(Dose for70kgAdult {gm/dosing interval in hours}):
CrCl: >80: 1/4-6; CrCl: 50-79: 1/4-6; CrCl:30-49: 1/4-6; CrCl:10-29: 1/4-6
- 10% of drug will be excreted in to urine (w/ nl RF(x))
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Cefotaxime vs nafcillin and tobramycin for the treatment of serious
infection. Comparative cost-effectiveness.
