- Discussion: 
- mild to moderate essential HTN
- edema of renal dz or cardiac failure, to potentiate effects of loop Diuretics
- inhibits NaCl resorption in corical diluting segment and in proximal tubule; HTN:2.5-5mg PO qd; 
- Edema: 5-20mg PO qd; 
- CHF: 5-10mg qd; 
- Potentiation of loops:2.5-10mg-titrated to effect; 
- Precautions: 
- Monitor fluid and electrolytes 2-10 mg qd will potentiate loop diruetics;

- Contraindicated w/ Anuria, hepatic coma or precoma; 
- Use caution when administering metolazone to hyperuricemia patients, patiets with severly impaired renal function, diabetics

Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Friday, December 16, 2011 4:03 pm