The Hip: Preservation, Replacement and Revision

Methicillin/Staphlocillin





- See: Penicillin Family

- For Staph;
- Adult: 4-18 gm 4-6hr; or Adult:100-200mg/kg/24hr;
- Watch for intersitial nephritis with high doses;
- Use high dose (12-18gm/day) for S. meningitis;
- Reduce dose w/ Renal Failure;
- Good diffusion from blood into CSF only with inflammation;
- Note: Ratio of CSF to Blood Level (%): Normal Meninges: nil;
    Inflammed Meninges: 10;
* w/ osteomyelitis
    Dose IV   time p admin.   Mean Ser conc (ug/ml)     Mean Bone conc (ug/gm)
  250 mg/kg   30-180 min.;       -----                       12.1
  1 gm         60 min;             17.1                       3.1




Original Text by Clifford R. Wheeless, III, MD.