Metformin / Glucophage - Wheeless' Textbook of Orthopaedics

- Discussion:
- oral hypoglycemic agent;
- note: some anesthesiologists will prefer to hold this agent on the day of surgery due to reports of uncontroled hypoglycemia during surgery;
- if this medication is given the morning of surgery, then serial blood sugars need to be taken on a serial basis throughout the case;
- dosage:
- usual starting dose is 500 mg PO bid given with the morning and evening meals;
- dosage increases should be made in increments of 500 mg each week, given in divided doses, up to a maximum of 2500 mg per day;
- w/ higher doses, this medication should be given on a tid basis;