The Hip: Preservation, Replacement and Revision

MAO Inhibitors

- See:
      - Isocarboxazid/Marplan
      - Tranylcypromine/Parnate
      - Phenelzine/Nardil

- Discussion:
    - can potentiate the depressive effects of narcotics;
    - can cause fever and seizures when administered to a patient receiving MAOI;
    - the pressor effect of indirectly acting agents such as ephedrine may be greatly exagerated;
    - the traditional recommendations are that MAOI be discontinued 2 weeks before surgery;
    - anticholinergic agents be avoided whenever possible;
    - meperidine should definitely be avoided, whereas  fentanyl or morphine appear to be suitable during Hanesthesia;
    - enflurane or isoflurane are preferred over halothane because of reduced arrhythmogenic potential;
    - due to the possibility of hypotension associated with spinal and epidural anesthesia and the subsequent requirement for basopressors general anesthesia is preferred.

Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Tuesday, July 3, 2012 2:40 pm