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Wheeless' Textbook of Orthopaedics
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Lactic Acidosis


- See: Metabolic Acidosis - develops during shock when there is inadequate cellular perfusion & cellular hypoxia; - caused by accumulation of lactate and hydrogen ions (protons), but extent of acidosis, as defined by pH, and the concentration of lactate required for diagnosis of lactic acidosis have never been accurately defined; - blood or plasma lactate concentration normally ranges from 0.5-1.5 mmol/L; Scoring systems and blood lactate concentrations in relation to the development of adult respiratory distress syndrome and multiple organ failure in severely traumatized patients.



Original Text by Clifford R. Wheeless, III, MD.