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Wheeless' Textbook of Orthopaedics

Isocarboxazid/Marplan


- Isocarboxazid is a MAOI - usual dose is 30 mg/day; - Isocarboxazid should be used with caution in combination w/ other monoamine oxidase inhibitors, tricyclic antidepressants, Carbamazepine, or cyclobenzaprine; - GEA and isocarboxazid may produce a combined hypotensive effect. - anticholinergic agents be avoided whenever possible; - meperidine should definitely be avoided, whereas fentanyl or morphine appear to be suitable during Hanesthesia; - enflurane or isoflurane are preferred over halothane because of reduced arrhythmogenic potential; - due to the possibility of hypotension associated with spinal and epidural anesthesia and the subsequent requirement for basopressors general anesthesia is preferred.



Original Text by Clifford R. Wheeless, III, MD.