Involvement of reactive oxygen species in post-ischaemic flap necrosis and

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its prevention by antioxidants. Suzuki S. Yoshioka N. Isshiki N. Hamanaka H. Miyachi Y. British Journal of Plastic Surgery. [JC:b0w] 44(2):130-4, 1991 Feb-Mar. In attempts to substantiate the possible participation of reactive oxygen species, and the significance of the xanthine oxidase system in both post -ischaemic reperfusion necrosis of the island flap and distal necrosis of the pedicle flap, and to develop new pharmacological measures for salvaging flap necrosis, a series of experiments were made using an island flap model and a random-pattern flap model in rats. The results were as follows: (1) Epoxysuccinyl derivative (E-64c), allopurinol and L-SOD salvaged post-ischaemic reperfusion necrosis of the island flaps; (2) E -64c and allopurinol did not salvage anticipated necrosis of the distal region of random flaps but L-SOD did; (3) tissue SOD activity did not reflect the fate of the island flap, but did of the distal region of the random flap. These results demonstrated a possible involvement of ROS in both post-ischaemic necrosis of island flaps and distal necrosis of random flaps. However, xanthine oxidase was significant in producing ROS only in the former. KDNkdn876yd2u Distally-based random fasciocutaneous flaps for multi-staged reconstruction of defects in the lower third of the leg, ankle and heel.