Ibuprofen/Motrin/Rufen/Advil/Nuprin



- Discussion:
     - for RA, OA, MSK pain, dysmenorrhea - NSAIA -
     - supplied: tabs: 200mg (OTC), 300mg, 400mg, 600mg, and 800mg;

- Adult:
     - 300, 400, 600, or 800 milligrams three times daily to four times daily
     - 1,200-3200 mg per day in divided doses (titrated as needed);
     - for mild to moderate pain: 400mg q4-6hr;
     - OA or RA: 400-800 mg tid/qid;

- Peds:
     - Antipyretic: 20 mg/kg/24hr divided q8hr;
     - Juvenile Rheumatoid Arthritis:  30-70 mg/kg/24hr divided tid/qid;

- Precautions:
     - metabolized in the liver
     - can cause GI upset, CNS symptoms, hepatotoxicity, and hematological toxicity - monitor renal failure;
     - contraindictated w/ Syndrome of Nasal polyps, bronchospastic activity and angioedema following ingestion of ASA and other NSAIA;
     - use with caution in patients with a history of GI bleeding, cardiac decompensation, HTN, impaired renal function, or bleeding disorders;
     - doncomitant administration of coumarin type anticoagulants may further increase PT



Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee

Effect of ibuprofen on the inflammatory response to surgical wounds.

Augmentation of critical skin flap survival following ibuprofen therapy.



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Tuesday, July 3, 2012 1:51 pm