- Discussion:
- for RA, OA, MSK pain, dysmenorrhea -
NSAIA -
- supplied: tabs: 200mg (OTC), 300mg, 400mg, 600mg, and 800mg;
- Adult:
- 300, 400, 600, or 800 milligrams three times daily to four times daily
- 1,200-3200 mg per day in divided doses (titrated as needed);
- for mild to moderate pain: 400mg q4-6hr;
- OA or RA: 400-800 mg tid/qid;
- Peds:
- Antipyretic: 20 mg/kg/24hr divided q8hr;
- Juvenile Rheumatoid Arthritis:
30-70 mg/kg/24hr divided tid/qid;
- Precautions:
- metabolized in the liver
- can cause GI upset, CNS symptoms, hepatotoxicity, and hematological toxicity - monitor renal failure;
- contraindictated w/ Syndrome of Nasal polyps, bronchospastic activity and angioedema following
ingestion of ASA and other
NSAIA;
- use with caution in patients with a history of GI bleeding, cardiac decompensation, HTN, impaired
renal function, or bleeding disorders;
- doncomitant administration of coumarin type anticoagulants may further increase PT;
Comparison of an antiinflammatory dose of ibuprofen, an analgesic
dose of ibuprofen, and acetaminophen in the treatment of patients
with osteoarthritis of the knee [see comments
Effect of ibuprofen on the inflammatory response to surgical wounds.
Augmentation of critical skin flap survival following ibuprofen therapy.
