- For mod - to severe
HTN & CHF; - Hydralazine can be used to effect transition from continuous infusion agents to bolous agents which in effects gets pt off "drip" (
Nitroprusside)
- Adult Dosing: - begin w/ 10mg PO qid for 2-4 days, then incr to 25mg qid, may incr to 50mg qid after 2 weeks, titrate to effect, - for rapid control of pressure: 10-40mg IV q 4-6 hrs; - use w/ caution; start w/ low doses; - Max of 300mg/day;
- Precautions: - doses > 300 mg may cause syndrome similar to
LUPUS; - must monitor Blood Pressure frequently, maximal hypotensive effect occurs within 20-80min; - Reflex Sympathetic
Tachycardia is treated with
Propanolol; - Use lower doses in Renal failure; - if
Tachycardia is seen during the hydralazine treatment, one may add
Beta blocker (esp.
Propanolol);
- Peds:
Hypertensive crisis: - 0.1-0.2 mg/kg/dose IM or IV q4-6 hr prn; - Chronic
HTN: 0.75-3.0 mg/kg/24hr PO divided q6-12 hr;
