Histology of Hyperparthyroidism
- Advanced Disease:
- osteoclastic resorption may become so severe that no bone is seen;
- there is granulation tissue w/ fibroblasts, giant cells, inflammatory cells, and macrophages, containing hemosiderin in many cases;
- this is characteristic of a brown tumor of hyperparathyroidism;
- due to increase in number of bone remodeling centers, there is increase in number of bites taken out of the bone at any one time, w/ a
resultant increase in the amount of bone which is missing at any one time;
- reduction in number of trabeculae;
- increase in multinucleated giated cells in Howship's lacunae;
- replacement of the normal cellular and marrow elements by fibrous tissue;
- brown tumors:
- occurs in severe cases;
- referred to as "giant cell tumor of diaphysis"
- microscopical exam revealed that it was composed of numerous osteoclasts with stromal hemorrhage
Original Text by Clifford R. Wheeless, III, MD.
Last updated by Data Trace Staff on Tuesday, December 6, 2011 1:13 pm