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Wheeless' Textbook of Orthopaedics
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GUANETHIDINE/ISMELIN


- for HTN; - Adult: - initially 10mg/24hr PO; - increase by 12.5mg/24 hr q5-7 days to 100mg/24 hr; - max dose of 300mg/24hr based on response; - Peds: 0.2 mg/kg/24hr PO initially; increase by 0.2 mg/kg/24hr increments q7-10 days; max dose of 3 mg/kg/24hr; - Precautions: - beware may produce profound orthostatic hypotension, esp w/ diuretic use; - may potentiate effects of vasopressor agents; increase bowel movements, and diarrhea possible;



Original Text by Clifford R. Wheeless, III, MD.