GUANETHIDINE/ISMELIN


for HTN
- Adult: 
- initially 10mg/24hr PO; 
- increase by 12.5mg/24 hr q5-7 days to 100mg/24 hr; 
- max dose of 300mg/24hr based on response; 
- Peds: 0.2 mg/kg/24hr PO initially; increase by 0.2 mg/kg/24hr increments q7-10 days; max dose of 3 mg/kg/24hr; 
- Precautions: 
- beware may produce profound orthostatic hypotension, esp w/ diuretic use;

- may potentiate effects of vasopressor agents; increase bowel movements, and diarrhea possible




Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Friday, December 16, 2011 2:29 pm