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Wheeless' Textbook of Orthopaedics
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Erythrocyte Sedimentation Rate



- See:
      - Orthopaedic Infections:
      - Sed Rate in THR:
      - Sed Rate: Osteomyelitis of the Spine:

- Discussion:
    - measurement of the increased rate of settling of erythrocytes is an important laboratory test in evaluation of
          disease activity in patients with connective-tissue diseases, certain infections, and neoplastic diseases;
    - a useful measure to follow the course of previously diagnosed specific illnesses;
    - westergren method;
          - normal values are 0-9 mm per hour for men & 0-20 mm/hr for women;
    - conditions which increase sed rate:
          - infection
          - inflammatory conditions
          - cancer (lymphoma, multiple myeloma)
          - pregnancy (third month to 1-month post partum);
          - surgery:
                - in routine orthopaedic procedures maximum of 25 to 100 mm / hour is reached at 4 days, which gradually decreases to nl over 1-2 weeks;
                - w/ more extensive surgery (THR) mild elevation may perist for upto one year;
          - heparinized blood;
    - conditions that decrease the sed rate:
          - rate may be "falsely low" in conditions in which red blood cells do not undergo rouleaux formation;
          - sickle cell anemia
          - hereditary spherocytosis;
          - cold agglutinin disease;
          - cachexia;




Erythrocyte sedimentation rate in infection of total hip replacements.

Periprosthetic low-grade hip infections. Erythrocyte sedimentation rate and C-reactive protein in 23 cases.

Erythrocyte sedimentation rate in infected and non-infected total-hip arthroplasties.

Sedimentation rate in infected and uninfected total hip arthroplasty.

Clinical significance of the erythrocyte sedimentation rate in orthopaedic surgery.

 Use of Erythrocyte Sedimentation Rate and C-Reactive Protein Level to Diagnose Infection Before Revision Total Knee Arthroplasty





Original Text by Clifford R. Wheeless, III, MD.