Efficacy of verapamil in the salvage of failing random skin flaps

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Nichter LS. Sobieski MW. Annals of Plastic Surgery. [JC:5vb] 21(3):242-5, 1988 Sep. Verapamil is a calcium channel blocker that inhibits mast cell degranulation, platelet aggregation, and neutrophil function and is a potent vasodilator. The efficacy of verapamil (20 mg/kg/day) to salvage a standard failing random skin flap in the rat was studied. In this study verapamil failed to benefit skin flap survival. The results are analyzed and presented.