- See:
Chemotherapy Agents: - Indications: - acute leukemias and malignant lymphomas; non-Hodgkin's lymphomas and Hodgkin's disease; ca of the ovary; breast; sm cell of lung; - Sarcomas:
Osteogenic sarc,
Ewing's, and soft tissue sarcomas; - Metastatic ca of Breast, ca of bladder, bronchogenic ca, neuroblastoma;
- Precautions: - care should be taken to avoid extravasation, since severe local vesicant action and tissue necrosis may result; - patients should be advised that the drug may impart red color to urine; - Cardiac toxicity is a unique characteristic of the anthracycline ATB's. - look for
ST changes on EKG; - may cause "pericarditis myocarditis syndrome" (See
Pericarditis); - may cause CHF which is resistant to
Digoxin - Cardiotoxicity may begin at 250 mg/sq m but usually does not begin until a total dose of approximately 500 mg/sq m; thereafter the risk increases markedly; - Note that Adriamycin is primarily metabolized and excreted by the liver, and must reduce the dose with renal failure. ----------------------------------
IIB osteosarcoma. Current management, local control, and survival statistics--Sao Paulo, Brazil.
Effects of chemotherapeutic agents on bone. I. Short-term methotrexate and doxorubicin (adriamycin) treatment in a rat model.
A prospective study of topical dimethyl sulfoxide for treating anthracycline extravasation.
