The Hip: Preservation, Replacement and Revision

Dopamine/Intropin/ Dopastat/

 


 - See: 
- Inotropic Agents 
- Indications for Dopamine:

 

* infuse at initial rate: 2-5 ug/kg/min, then titrate to effect, 
* max = 50 ug/kg/min based on effect; 
* at 2 - 5 ug/kg/min: dilates renal, & intestinal arterioles; 
* 2-10ug/kg/min (Beta > Alpha); (ideal dose range) 
- positive inotrop; increases CO
* 10-20 ug/kg/min (alpha >> B): 
- peripheral vaso-constriction, increases BP, increased systemic resistance; 
- > 15 ug/kg/min may/will decrease Renal Perfussion; monitor urinary output; 
- dosage is too high when there is unacceptable incr. in heart rate, SVR, PCWP pressure, orarrhythmias; 
- Precautions: 
- dopamine increases Wedge Pressure and requires monitoring of wedge pressure; 
- dopamine should be used for inotropic support and low SBP only when Dobutamine has failed; 
- monitor EKG for Tachycardia
* Supplied: Injection 40 mg/ml, 80 mg/ml, 160 mg/ml; 
- Setting the Dosage
- set microdrip controller to equal the number of ug/kg/min of dopaime; 
- patient wt(kg) x 15 = amount of dopamine (mg) added to 250 ml of D5W; 
- setting of 10 microdrops then approximates 10 ug/kg/min being infused; 
- contents of 1 to 2 ampules (400 ug/amp) is mixed in 250 ml of 5% dextrose; 
- this yeilds concentration of 1600 or 3200 ug/ml, respectively


The renal effects of low-dose dopamine in thermally injured patients

Effects of Hypothermia on Hemodynamic Responses to Dopamine and Dobutamine



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Wednesday, April 11, 2012 3:17 pm