Orthopaedic Jobs

Diphenhydramine/Benadryl


- Discussion:
    - for motion sickness, potentiation narcotics, sedation, cough supression, for allergic reactions, for extrapyramidal reactions;
    - adult: 25-50mg PO/IM/IV (slow direct injection) bid-tid;
    - ananti-histamine with many anticholinergic effects including dry mouth, urinary retention;
    - increase dosing interval in moderate to severe renal failure;
    - peds: 5mg/kg/24hr PO or IM in 4 divided doses;
    - supplied: Tabs and Caps: 25mg, 50mg; injection 10 mg/ml, 50 mg/ml; syrup 12.5 mg/5ml;
    - antihistamines are the active ingredients in most over-the-counter sleep preparations, and although often effective, they are associated with a
                  higher risk of delirium than are the benzodiazepines in the elderly



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Clifford R. Wheeless, III, MD on Monday, August 4, 2014 8:03 pm