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Wheeless' Textbook of Orthopaedics
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Digoxin: Interactions and Toxicities


- Digoxin metabolism is Inhibited by: - Erythromycin - Tetracycline - quinidine may double Dig levels; - Verapamil and Amiodarone - Hypokalemia and HypoMagnesemia and Hypoxia will potentiate toxicity, - Digoxin bioavailability is decreased by: - cholestyramine, - KAOLIN-pectin - antacids; - Can cause heart block; - Toxicity = N/V, diarrhea, HA, GI symptoms, anorexia, pyschiatric, fatique, visual lesions (yellow-green halos around lights) & cardiac arrthymia;



Original Text by Clifford R. Wheeless, III, MD.