- Adult: 0.5-1gm q 6hr PO or 12.5mg/kg/24hr;
- Dosing Regimens for Patients with Renal Insufficiency:
(Dose for70kg Adult {gm/ dosing interval in hours})
CrCl: >80; 0.5/6; CrCl:50-79::0.5/6; CrCl:30-49; 0.5/6; CrCl:10-29: 0.5/6
- 40 % of dose will be excreted in urine (w/ nl R F(x))
- Bad Taste (bad for Chlidren)
- Peds Dose: 25-50 mg/kg/day q 6hr;
- Will interact with
Warfarin to Decrease PT;
- w/
osteomyelitis
Dose IM
time p admin.
Mean Ser conc (ug/ml)
Mean Bone conc (ug/gm)
50 mg/kg
60-180 min
- - - - -
6.4
- supplied: 125, 250 mg;
----------------------------------------
Oral treatment of less severe infections (e.g., dermal) can be
carried out with dicloxacillin or cloxacillin (or cephalexin,
erythromycin, or trimethoprim-sulfamethoxazole, if the patient is
allergic to penicillin).
Interestingly, dicloxacillin is well
absorbed orally and results in blood levels nearly comparable to
those resulting from parenterally administered drug;
- thus,
many stable patients with deep-seated but quiescent disease can be
effectively treated with oral dicloxacillin for the final days (or even weeks) of
defined, prolonged course of therapy.
