The Hip: Preservation, Replacement and Revision

Dicloxacillin/dynapen


- Adult: 0.5-1gm q 6hr PO or 12.5mg/kg/24hr;
- Dosing Regimens for Patients with Renal Insufficiency:
 (Dose for70kg Adult {gm/ dosing interval in hours})
  CrCl: >80; 0.5/6; CrCl:50-79::0.5/6; CrCl:30-49; 0.5/6; CrCl:10-29: 0.5/6
- 40 % of dose will be excreted in urine (w/ nl R F(x))
- Bad Taste (bad for Chlidren)
- Peds Dose: 25-50 mg/kg/day q 6hr;
- Will interact with Warfarin to Decrease PT;
- w/ osteomyelitis
  Dose IM  time p admin.  Mean Ser conc (ug/ml)    Mean Bone conc (ug/gm)
  50 mg/kg  60-180 min       - - - - -                  6.4
- supplied: 125, 250 mg;

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      Oral treatment of less severe infections (e.g., dermal) can be carried out with dicloxacillin or cloxacillin (or cephalexin, erythromycin, or trimethoprim-sulfamethoxazole, if the patient is allergic to penicillin).  Interestingly, dicloxacillin is well absorbed orally and results in blood levels nearly comparable to those resulting from parenterally administered drug;

  - thus,  many stable patients with deep-seated but quiescent disease can be  effectively treated with oral dicloxacillin for the final days (or even weeks) of defined, prolonged course of therapy.



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Tuesday, July 5, 2011 2:58 pm