Diagnosis of eosinophilic granuloma of bone by cytology, histology, and electron

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microscopy of transcutaneous bone-aspiration biopsy. Katz-RL; Silva-EG; deSantos-LA; Lukeman-JM J-Bone-Joint-Surg-Am. 1980 Dec; 62(8): 1284-90 The cytological, histological, and ultrastructural morphology of transcutaneous bone aspirates from five patients with eosinophilic granuloma of bone were studied. Use of this combined approach enabled us to make a definitive diagnosis of eosinophilic granuloma from a small quantity of tissue without having to resort to open biopsy. By light microscopy, eosinophilic granuloma is composed of a polymorphous infiltrate of characteristic lobulated histiocytes, eosinophils, polymorphonuclear leukocytes, and giant cells. Each specimen examined ultrastructurally demonstrated the characteristic Langerhans granule-containing histiocyte. Eosinophilic granuloma is a benign lesion which is readily diagnosed by this technique, and more aggressive diagnostic procedures usually are not warranted.