Combination drug therapy in treatment of Paget's disease of bone

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clinical and metabolic response. Hadjipavlou-AG; Tsoukas-GM; Siller-TN; Danais-S; Greenwood-F J-Bone-Joint-Surg-Am. 1977 Dec; 59(8): 1045-51 Twenty-seven patients with symptomatic Paget's disease of bone were randomly treated with mithramycin, glucagon, and calcitonin given either alone or in combination. Mithramycin, at a dose of fifteen micrograms per kilogram of body weight per day, proved to be a relatively safe drug and elicited a rapid response with only transient side effects. Calcitonin combined with mithramycin was the most effective therapy.