SOMOS Annual meeting
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presents
Wheeless' Textbook of Orthopaedics

CLOZAPINE/CLOZARIL




- antipyschotic med, for chronic pyschotic patients who are resistant
    to usual medications; Both active and passive symptoms may improve with
    this medication;
- Side effects include Agranulocytosis in 1-2% of patients;
- WBC < 3000 or ANC < 1500 calls for interuption of treatment;
- Also note dose related increase risk of seizures;
- at 300mg/day, increase risk of seizure is 1-2%; at 600mg/day incr risk
    is 3-4%;
- Marked sedation, tachycardia, and hypotension are also seen;



Original Text by Clifford R. Wheeless, III, MD.