Chlorpromazine/Thorazine


- may be used to control severe HTN which does not respond to Nitroprusside, use Thorazine w/ caution;
    - begin w/ 2.5 mg IV bolus, repeating prn q 5-10 min to max dose of 15 mg;
    - must have liter of crystaloid ready for infussion, if profound hypotension occurs;
- for psychotic, Nausea, Vomiting; Adult anxiety: 10-25mg PO bid/tid;
- severe symptoms: 25mg IM, can repeat in 1 hr, then 25mg PO bid/tid;
- Note Side Effects: Sedative=Strong; Hypotensive=Strong; Anticholinergic=Intermediate;  EPS=Weak;
- Note: lowers Seizure Threshold;
- Peds: > 6 months: 0.55 mg/kg/dose q6-8hr IM or IV; maximum of 40 mg/24hrs for < 5yrs or 75 mg/24hrs for 5-12 yrs; 0.5mg/kg/dose PO q4-6hr



Intramuscular meperidine, promethazine, and chlorpromazine: analysis of use and complications in 487 pediatric emergency department patients.



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Tuesday, July 3, 2012 12:33 pm