CHLORAMPHENICOL/CHLOROMYCETIN





      For serious infections caused by Gram Positive Cocci and bacilli;
gram Negative aerobic and anaerobic bacteria; (Pseudomonas)
almost always resistant.   Adult: 25-100mg/kg/day PO or IV in 4 divided doses;
Note aplastic anemia, monitor CBC, reduce dose with hepatic
impairment; oral agents should by used whenever possible as the oral
products are more bioavailable than the injection; use with caution in
premature and newborn infants (gray baby syndrome);
    decrease dose with renal or hepatic failure; Contra w/ preexisting BM
failure; must obtain CBC, other blood studies before therapy; Note:
Diffusion from blood into CSF adequate w/ or w/o Inflammation; Note:
RatioofCSF to BloodLevel (%): NormalMeninges: 66; Inflammed
Meninges: 66+;; DosingRegimensforPatients withRenal Insufficiency:
(Dose for 70kg Adult{gm/dosinginterval inhours}): CrCl:>80::
0.75/6;; CrCl:50-79:: 0.75/6;; CrCl:30-49:: 0.75/6;; CrCl:10-29::
0.75/6;; Note: visual disturbances; Paresthesia: Peripheral
Neuropathy: Hallucinations; Requires Dose Reduction in Hepatic
Dysfunction; Adult: 25-100 mg/kg/day PO or IV in 4 DD;   In patients of
mediterranean ancestry, may cause hemolysisin pt w/ G6PD deficiency; Note:
Aplastic anemia has been associatted with the use of this agent; monitor
hematology labs carefully; reduce dose with hepatic impairment; oral agents
should be used whenever possible as the oral products are more bioavailable
than the injection; use with caution in premature and newborn infants (gray
baby syndrome); Peds: < 1 week: 25 mg/kg/24hr IV divided q12hr; >2 weeks: 50
mg/kg/24hr IV divided q12hr; >4wks: 50-100 mg/kg/24hrs IV or PO divided q6hr;




Original Text by Clifford R. Wheeless, III, MD.