- See:
first generation ceph
- Discussion:
- adult: 1-4 gm/day PO given in 4-6 hr intervals; Max 4gm per 24 hrs;
- 250 to 500mg PO q6hr for
UTI; t1/2=1hr;
- may give with Probenicid w/ osteomylitis for 2-4wks IV;
- contra with cephalo allergy;
- dosing regimens for patients w/ renal insufficiency: (dose for 70 kg adult gm/dosing interval in hours;
- CrCl: >80:0.5/6; CrCl:50-79:0.5/6;
- CrCl:30-49:0.5/8; CrCl:10-29:0.5/12;
- 90 % of dose will be excreted in urine (w/ nl R F(x))
- note 10-15% cross reactivity with penicillin allergic patients;
- peds: 25-50 mg/kg/24hr q 6;
- supplied: 250 mg caps, 250 mg suspension;
Efficacy of perioperative cefamandole with postoperative cephalexin in the primary outpatient treatment of open wounds of the hand.
