Cefuroxime/Zinacef



- Discussion:
    - second generation ceph
    - cefuroxime is effective in therapy of cases of community-acquired pneumonia in which ampicillin-resistant H.  influenzae is a possible etiologic agent cefoxitin;
    - adult dose:
         - 0.75-1.5gm q6-8hr IV or 3gm q8hr IV w/ meningitis;
         - cefuroxime axetil: 125-250 mg PO WC PO q12hr;
    - peds: (4 wks-4 yr): 100-150 mg/kg/24 hr;
         - good for H.influenza, N.gonorrhea w/ B lactamase:
         - decrease dose with renal failure, contra with allergy to cephalo and caution with allergy to penicillin;
    - inject .75, 1.5, 7.5; t1/2 = 1.5hr;
    - menigitis:
         - good diffusion from blood into CSF only with inflammation;
         - note: ratio of CSF to Blood Level (%): Normal Meninges: nil; Inflammed Meninges: 6-16;
    - dosing regimens for patients with renal insufficiency:
         - dose for 70kg adult{gm/dosing interval in hours}): CrCl: >80: 0.75-1.5/8; CrCl: 50-79: 0.75-1.5/8; CrCl:30-49: 0.75/8; CrCl:10-29::0.75/12;
         - 90 % of dose will be excreted in urine (w/ nl R F(x))



Cefuroxime in total joint arthroplasty. Intravenous or in bone cement.

Biomechanical properties of bone cement with addition of cefuroxime antibiotic.

Biofilm formation by bacteria isolated from retrieved failed prosthetic hip implants in an in vitro model of hip arthroplasty antibiotic prophylaxis.

Bacterial contaminants and antibiotic prophylaxis in total hip arthroplasty.



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Friday, November 30, 2012 3:22 pm