- Discussion:
- second generation ceph
- cefuroxime is effective in therapy of cases of community-acquired pneumonia in which ampicillin-resistant H. influenzae is a possible etiologic agent cefoxitin;
- adult dose:
- 0.75-1.5gm q6-8hr IV or 3gm q8hr IV w/ meningitis;
- cefuroxime axetil: 125-250 mg PO WC PO q12hr;
- peds: (4 wks-4 yr): 100-150 mg/kg/24 hr;
- good for H.influenza, N.gonorrhea w/ B lactamase:
- decrease dose with renal failure, contra with allergy to cephalo and caution with allergy to penicillin;
- inject .75, 1.5, 7.5; t1/2 = 1.5hr;
- menigitis:
- good diffusion from blood into CSF only with inflammation;
- note: ratio of CSF to Blood Level (%): Normal Meninges: nil; Inflammed Meninges: 6-16;
- dosing regimens for patients with renal insufficiency:
- dose for 70kg adult{gm/dosing interval in hours}): CrCl: >80: 0.75-1.5/8; CrCl: 50-79: 0.75-1.5/8; CrCl:30-49: 0.75/8; CrCl:10-29::0.75/12;
- 90 % of dose will be excreted in urine (w/ nl R F(x))
Cefuroxime in total joint arthroplasty. Intravenous or in bone cement.
Biomechanical properties of bone cement with addition of cefuroxime antibiotic.
Bacterial contaminants and antibiotic prophylaxis in total hip arthroplasty.