Orthopaedic Jobs

Ceftazidime/Fortaz/Tazidine


- See: Third Generation Cephalosporin

- Adults: 25 to 150 mg/kg/day IV;
- Peds: 100-150 mg/kg/day q8hr;
- good for Pseudomonas, Gm Neg Eneteric, NonEnterococci Strep; moderate to poor activity against strep; mod to good (85%) against Staph;
- No activity against B.fragilis or enterococci;
- Uncomplicated UTI: 250mg IV/IM q12hr;
- Complicated UTI: 500mg-1gm IV/IM q8-12hr;
- Uncomplicated Pneumoniae and mild skin infections: 500mg-1gm q8hr;
* Bone and joint infections: 2gm IV q12hr;
- Meningitis, serious gyn infections, and intra abdominal infections:
    - 2gm IV q8h;
- Psuedomonal lung infections in patients with CF: 30-50mg/kg IV q8hr, up to 6gm/day;
- Usual recomended dosage upto 1gm IV/IM q8-12hr;
- Contra with cephalo allergy, caution with Penicillin allergy;
- Good diffusion from blood into CSFonly with inflammation;
    Ratio of CSF to Blood Level (%): Normal Meninges: <1;
    InflammedMeninges: 20-40;
- Dosing Regimens for Patients with Renal Insufficiency: (Dose for 70kg Adult{gm/dosing interval in hours}):CrCl: >80:1/8; CrCl:50-79:1/8; CrCl:30-49:1/12; CrCl:10-29:1/24;
    - in dialysis patients give a 1 gm supplement dose;
    - 75 % of dose will be excreted in urine (w/ nl R F(x))
- Ceftazidime:
    - is not as active as the other third-generation cephalosporins against gram-positive cocci, although it is similar to cefotaxime in its activity against the Enterobacteriaceae.
    - is most potent of 3rd-generation cephalosporins against Ps.aeruginosa;
    - 90 % of strains are susceptible to less/= 8 microgram per milliliter;
    - ceftazidime has little activity against most anaerobes


Ceftazidime in treatment of urinary tract infection in patients with spinal cord injury: comparison with moxalactam.



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Friday, November 30, 2012 3:15 pm