Cefoperazone/Cefobid


- Third Generation Cephalosporin
- Do Not use alone with Pseudomonas;
- Adult: 100-150mg/kg/24hr q8-12hr IV; t1/2 = 2.5hr;
- Hepatic and renal excretion allows normal dosing in Renal failure;
- Disulfiram reaction and hypothrombinemia;
- Good diffusion from blood into CSF only with inflammation;
- Dosing Regimens for Patients with Renal Insufficiency: (Dose for 70kg Adult {gm/dosing interval in hours}): CrCl: >80::2/12; CrCl:50 29::2/12; CrCl:30-49::2/12;; CrCl:10-29::2/12;;
    - 20-30 % of dose will be excreted in urine;
- Will interact with Oral Anticoagulants and Alcohol;
- Note: the presence of the MTT side chain on cefotetan, Cefamandole, and Cefoperazone has been associatted with bleeding complications which may be worse with renal failure



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Friday, November 30, 2012 3:04 pm