-
Second Generation Ceph
- Semisynthetic cephalosporin: for surgical prophylaxis:
- 1gm 1hr given preoperatively;
- Severe infections: 2gm qd IV/IM;
- Mild to Moderate infections: 1gm qd IV/IM;
- Uncomplicated
UTI: 500mg qd IV/IM;
- Dosing Regimens for Patients with Renal Insufficiency: (Dose for 70kg
Adult{gm/dosing interval in hours}):CrCl: >80::1/24;; CrCl:50-79::
1/24;; CrCl:30-49::1/24;; CrCl:10-29::1/48;;
- 99 % of dose will be excreted in urine;
Cefonicid, because of its long half-life of 4.5 hours, has been used
successfully in a regimen in which it is administered once a day to
treat a variety of mild to moderate infections, including
community-acquired pneumonias, urinary tract infections, and infections
of the skin and soft tissue;
----------------------
Prophylaxis against infection. Single-dose cefonicid compared with
multiple-dose cefamandole.
Duration of preventive antibiotic administration for open extremity
fractures.
