Cefazolin/Ancef


- See:
        - first generation ceph
        - antibiotic prophyalxis

- Adult: 0.5-2gm q8hr IM/IV; t1/2=2h; Max dose: 6 gm/24hr;
        - surgical prophylaxis: 1gm IM/IV 30-60min before surgery and 500mg - 1gm q6-8hr afterwards for 24hr;
- Peds: ( > 4 yrs): 100 mg/kg/24 hr

- Caution:
    - w/ allergy to Penicillin and contraindicated with allergry to cephalosporin;
    - Dosing Regimens for Patients with Renal Insufficiency:  (Dose for 70 kg Adult (gm/dosing interval in hours)):
           - 70-80 % of dose will be excreted in urine;
           - CrCl > 80  1 q  8, CrCl 50-79    1 q  8, CrCl 30-49    1 q 12, CrCl 10-29    0.5 q 12


- w/ osteomyelitis:

Dose IV Time p Admin. Mean Ser conc (ug/ml) Mean Bone conc (ug/gm)
50 mg/kg 180 min 10 4
1 gm 50 70  15


 Are Bone and Serum Cefazolin Concentrations Adequate for Antimicrobial Prophylaxis? 


- References



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Friday, November 30, 2012 2:53 pm