-
Second Generation Ceph
- Semisynthetic broad spectrum cephalosporin - Gen II.
- Adult:500mg-1gm IV/IM q4-6hr to max dose of 12gm/day (2gm q4hr);
- usual dose is 1gm q6hr;
- Peds: 50-100 mg/kg/day q6hr;
- Good diffusion from blood into CSF only with inflammation;
Ratio of CSF to Blood Level (%): Normal Meninges: nil;
Inflammed Meninges: 0.5-20 (if protein > 100mg%;
- Dosing Regimens for Patients with Renal Insufficiency: (Dose for 70kg
Adult {gm/dosing interval in hours}): CrCl: >80:1/4-6; CrCl:50-79:1/6;
CrCl:30-49:1/8; CrCl:10-29:1/8;
- 65-85 % of dose will be excreted in urine;
- Note: the presence of the MTT side chain on
cefotetan, Cefamandole,
and
Cefoperazone has been associatted with bleeding
complications which may be worse with renal failure;
-----------------------------------------------
Cefazolin versus cefamandole for prophylaxis during total joint
arthroplasty.
Prophylaxis against infection. Single-dose cefonicid compared with
multiple-dose cefamandole.
Duration of preventive antibiotic administration for open extremity fractures.
Cephalothin and cefamandole penetration into bone, synovial fluid,
and wound drainage fluid.
Efficacy of perioperative cefamandole with postoperative cephalexin in
the primary outpatient treatment of open wounds of the hand.
Timing of antibiotic administration in knee replacement under tourniquet.
