- See:
-
AnitPseudo
-
Penicillin Family
- Useful for infections caused by
Pseudomonas and Proteus;
- There are small differences in the pattern of activity of these
agents against gram-negative organisms.
Ticarcillin is two to four
times more active than carbenicillin against
P. aeruginosa
- more active against gram positive organisms;
- Adult: 4-8 gm q4hr Injection/PO;
- When used alone note appearance of resistent gram negative bacteria;
- For uncomplicated
UTI: 500mg tab PO q6h or 1-2 gm IM/IV q6h;
- Serious
UTI: 200mg/kg/day by continuous infusion;
- For serious infections outside the urinary tract: 300-500 mg/kg/day in
divided doses or by continuous infusion;
- w/
osteomyelitis
Dose IV
time p admin.
Mean Ser conc (ug/ml)
Mean Bone conc (ug/gm)
5gm/4hr
90 min
204
24.5
- Dosing Regimens for Patients with Renal Insufficiency: (Dose for70kg Adult
{gm/dosing interval in hours}):CrCl:>80:3/4-6; CrCl:50-79:3/4-6;
CrCl:30-49::3/6-8;; CrCl:10-29::3/8-12;;
- Note high sodium content (4.7mEq Na/gm) or parental
Carbenicillin, may
produce fluid overload;
- Good diffusion from blood into CSFonly with inflammation, but insufficient
for
Pseudomonas; Ratio of CSF to Blood Level (%):
Normal Meninges: 15; Inflammed Meninges: 20;
- Will interact with
aminoglycosides, Oral Anticoagulants, Oral contra;
;
