- See: -
Enalapril -
Antihypertensive - Angiotensin Coverting Enzyme Inhibitor - For
HTN & CHF which is not controled w/
Diuretics &
Digitalis; - Adult:
HTN: start w/ 6.25 mg to 25 mg PO bid/tid, titrate individual dose over 1-2 wks w/ 25mg increments; w/ CHF initially 6.25-12.5mg tid & titrate; - Peds: Infants: 0.5-6.0 mg/kg/day PO divided q6-24hrs; - Older children: 12.5 mg/dose PO q12-24hr; - Give 1hr before meals; - Max dose = 150mg/day divided in 3 doses; - Decrease dose in Renal Failure; - Need to get CBC and Urinalysis prior to usage;
Captopril: Interactions and Toxicities: - Contraindicated with renal artery stenosis; caution w/ Collagen vasc. dz; - May Cause: Rash, Proteinuria, Membranousglomeropathy, Nephrotic synd., Leukopenia and Cough; - must be careful w/ concomitant use of
Diuretics; - use smaller doses & watch for exaggerated hypotensive effects; -
Diuretics should be added if the BP response to ACE is insufficient; - potassium sparing
Diuretics should be avoided, because they may potentiate hyperkalemic effect; -
Indomethacin may attenuate the acute response to captopril;
