Bone Scans in the Diagnosis of Bone Crisis in Patients Who Have

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Gaucher Disease. Katz-K. Mechlis-Frish-S. Cohen-I-J. Horev-G. Zaizov-R. Lubin-E. The Journal of Bone and Joint Surgery (American Volume). 1991 Apr. 73-A(4). pp 513-517. AB ABSTRACT: Of thirty-four occurrences of bone pain in seventeen children and young adults who had type-I Gaucher disease, twenty-five were finally diagnosed as bone crises. On the basis of a bone scan with technetium-99m methylene diphosphonate, a correct diagnosis of bone crisis was made for twenty-three occurrences, with a sensitivity of 0.92. At the onset of a crisis, the bone scan typically showed decreased uptake of radionuclide at the involved site. After six weeks, a repeat bone scan of the long bones showed a ring of increased uptake surrounding an area of decreased uptake. At six months, the appearance of the bones on the radionuclide scan was normal.