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Wheeless' Textbook of Orthopaedics

Bacteriology of Orthopaedic Infections in Neonates



- See:
      - Osteomyelitis in NewBorn
      - Septic Hip

- Bacteriology:
    - in hospital-acquired cases, staphylococci are the predominant isolates (about 60%),
          followed by Group B streptococcus, candida & gram-negative bacilli;
          - these infections often stem from invasive procedures such as catheterization of the
                umbilical vessels, central lines, and intra-osseous lines;
    - in community-acquired septic arthritis, Group B. streptococci are the most frequent
          (52 %), followed by staphylococci (26 %) & gonococci (17%);
          - this usually means oxacillin 200 mg/kg/day and gentamycin 7.5 mg/kg/day;
    - in infants and children 1 month to 3 years old, the predominant organism causing hematogenous septic arthritis
          was historically was haemophilus influenzae, followed by staphylococci and streptococci;
          - predominance of H. influenza has significantly declined since a vaccine has been developed;
          - in the study by H. Peltola et al. 1998, the incidence of haemophilus influenza septic arhtritis was 0% after
                10 years of routine vaccination;
                - Reduced incidence of septic arthritis in children by H. influenza type B vaccination.
                        H. Peltola et al.   JBJS. Vol 80-B. No 3. May 1988. p 471.

- Treatment Agents:
    - oxacillin)
    - cephalosporin type III (rocephin)





Septic arthritis in young infants: clinical and microbiologic correlations and   therapeutic implications.
    M. Dan.   Rev. Infectious Diseases.   Vol 6. 1984. p 147-155.

Long-term follow-up of infantile hip sepsis.
    Wopperer JM, White JJ, Gillespie R, et al: J Pediatr Orthop 1988;8:322-325.

Sequelae and reconstruction after septic arthritis of the hip in infants.
    Choi IH, Pizzutillo PD, Bowen JR, et al:   J Bone Joint Surg 1990;72A:1150-1165.

Etiology and medical management of acute suppurative bone and joint infections in pediatric patients.
    Jackson MA, Nelson JD:   J Pediatr Orthop 1982;2:313.

Antibiotic concentrations in septic joint effusions.
    Nelson JD:   N Engl J Med 1971;284:349.













Original Text by Clifford R. Wheeless, III, MD.