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- for short term management of of CHF if patient to respond to Digitalis, Diuretics, and vasodilators; 
- used for patients w/ severe CHF refractory to diuretics, vasodilators, and conventional inotropic agents. 
- potent inotropes and vasodilators; 
- amrinone & milrinone decr systemic, pulmonary, & coronary vascular resistance; 
- this effect can lead to decreases mean arterial pressure, esp in hypovolemic pt; 
- can be used to reduce afterload, but in many situations vasoconstrictors must be used to prevent vascular collapse; 
- Adult Dose: 
- initially give IV bolus of 0.75 mg/kg over 2-3min. followed by maintainace dose of 5-10ug/kg/min; 
- may repeat bolus dose 30min after maintainance infusion if needed; 
- not to exceed 10mg/kg/day; 
- Misc: 
- incompatible with dextrose containing solutions; monitor for fluid and electrolyte changes and renal function during Rx

Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Wednesday, December 14, 2011 3:06 pm