- See:
-
Penicillin Family
-
Ampicillin
-
References
- Discussion:
- for beta lactamase producing
Staph aereus,
Eneterococcus,
H. influenza,
Klebsiella, Proteus mirablis,
Bacteroides
- adult: 1.5-3 gm IM/IV q6hr (2:1 ampicillin sodium:sulbactam) adjust w/ Renal failure;
- good diffusion from blood into CSF only with inflammation;
- inflammed meninges: 5-10;
- dosing regimens for patients with renal insufficiency;
- dose for 70 kg Adult {gm/dosing interval in hours} CrCl >80: 1.5-3/6-8; CrCl:50-79: 1.5-3/6-8; CrCl:30-49: 1.5-3/6-8; CrCl:10-29: 1.5-3/12;
- note prophylaxis of Bacterial
endocarditis:
Amp 2.0gm IM or IV 30min
before procedure +
Gent 1.5mg/kg IM or IV 30min before procedure;
- watch for hypersensitivity, erythematous maculopapular rash occurring 2-4 weeks after 1st dose;
- peds: Dosed as Ampicillin;
- supplied: Powder for Injection 1.5 gm, 3.0 gm vials;
- Sulbactam:
- is semisynthetic beta-lactamase inhibitor w/ activity against a broad range of beta-lactamases, including those
produced by bacteroides,
Haemophilus,
Klebsiella,
E. coli,
and
N. gonorrhoeae;
- it is currently available as parenteral preparation in combination w/ ampicillin (Unasyn -- 2 g of ampicillin and 1.0 g of sulbactam);
- given every six hours, combination has been successful in treatment of variety of infections, including intraabdominal
& pelvic infections, infections of the skin, soft tissue, and bones and joints, and uncomplicated urethritis
caused by penicillin-sensitive and penicillin-resistant N. gonorrhoeae;
- overall, clinical experience with sulbactam remains limited;
