Mixture Interactions References - Should be delivered via Central Line; - For severe systemic fungal infections; - Dose: 0.25mg/kg IV over 6hrs initially (infusion .1mg/ml); - gradually increase dose as tolerated up to 1-1.5mg/kg/24hrIV over 6hr; - Note hypersensitivity, caution with nephrotoxic/antineoplastic agents; - monitor blood, liver, and renal function, - Discontinue therapy if BUN >40mg/dl, Creatinine >3.0mg/dl, or if liver function test abnormalities are noted; - Pretreatment with ASA, acetaminophren, and antihistamines (Benadryl) helps minimize adverse effects; - small amounts of heparin (1unit/ml) and hydrocortisone (2.5mg/mg
Ampho) added to the infusion may help minimize phlebitis; - may consider 1mg test dose over 30min; - May also apply as a cream to supperficial
Candida; - May also cause
hypokalemia, fever; - Note Diffusion from Blood into CSF is NIL even w/ Inflammation; - Dosing Regimens for Patients with Renal Insufficiency: (Dose for 70kg Adult {gm/dosing interval in hours}):CrCl:>80:0.02-0.05/24; CrCl:50-79:0.02-0.05/24; CrCl:30-49:0.02-0.05/24; CrCl:10-29:0.02-0.05/24; - 40% of drug excreted in urine over 7 days; - Will interact with
aminoglycosides (Incrnephrotoxicity), Digitalis and Neuromuscular blocking agents (due to
Ampho induced Hypokalemia); - Note: may cause HypoMagnesemia;
* As a Bladder Irrigant - - r/o fungus ball in the renal pelvis; - effective in 3/4 of patients - virtually no absorption - no toxicity - usual dose is 50 mg Ampho B / 1000 ml sterile water - this concentration may be toxic to uroepithelium; - try: 5.0 mg/liter
