Amantidine




    for Parkinsonism, drug induced extrapyramidal reactions, prophylaxis of
Influenza A and treatment of Influenza if seen < than 20hrs after onset of
illness;; has ability to release dopamine; Adult: for drug induced
etrapyradimal reactions:100 mg PO bid; for parkinsonism: 100mg PO qd
initially, then may increase gradually to maximum of 400 mg qd in divided
doses; Prophylaxis of Influenza A:100 mg PO bid; If pt >65yrs or has active
seizure disorder: 100mg PO qd;; Note must decrease dosage in Renal
insufficiency, CHF, peripheral edema, or orthostatic hypotension;
Note that
Parkinsoncrisis may be caused by abrupt d/c of drug; Contraindications: Note
drug hypersensitivity, lactation; Use caution in patients with history of
seizures (increase risk of seizure activity), CHF, peripheral edema, Liver
disease, recurrent eczematous rash, psychosis or psychoneurosis not controlled
by chemotherapeutic agents; Note Side Effects: Jitteriness, Inability to
concentrate, Insomnia, Tremors, Confusion, Depression, Hallucinations, CHF,
Orthostatic Hypotension, urinary retention; Incidence low (6% Withdrawals,
none after first week) & is dose related; Rash, Nausea; Teratogenic; Note that
immunization remains primary for prevention of influenza A; Efficacy 70% in
prevention Therapy:50% decr duration of sx; t/2 12hrs, markedly incr with
renal failure; Saftey inpregnancy; DosingRegimens for Patients with Renal
Insufficiency: (Dose for 70kg Adult{gm/dosing interval in hours}):
CrCl:>80::0.1/12;; CrCl:50-79::0.1/24;; CrCl:30-49::0.1/24;;
CrCl:10-29::0.1/72;; Hallucinations; Will Interact w/: Anticholinergic and
Antiparkinson agents, Thiazide type diuretics, and Triamterene; look for
increased dry mouth, ataxia, blurred vision, slurred speech, toxic pyschosis;
Peds: Influenza A prophylaxis: 1-9 yrs; 4.4-8.8 mg/kg in 2-3 DD upto 150
mg/day; > 9 yrs gets adult dosage; Capsules 100 mg, syrup 50 mg/5ml;



Original Text by Clifford R. Wheeless, III, MD.