A comparative study on the effect of various pharmacological agents on the

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survival of skin flaps in the rat. Suarez Nieto C. Suarez Garcia MJ. Barthe Garcia P. British Journal of Plastic Surgery. [JC:b0w] 45(2):113-6, 1992 Feb-Mar. The effects of chlorpromazine, pentoxifylline, terbutaline, allopurinol, phenoxybenzamine, naftidrofuryl, hydralazine and trimetazidine were investigated on caudally based dorsal flaps. The study was performed on 108 rats, divided in 9 groups of 12 animals each, one of which served as a control group. All treated groups showed a significantly greater survival of the flap than the control group. Comparisons among different groups showed better outcome in those receiving trimetazidine and hydralazine, followed by those receiving naftidrofuryl and phenoxybenzamine.