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Wheeless' Textbook of Orthopaedics
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C - Reative Protein

- See orthopaedic infections:


- Discussion:
    - an acute phase protein that can be used to follow the course of acute infections;
    - it rises and falls faster than the ESR;
    - 10 mg per liter is used as the threshold for total hip infection infection;  
          - using this threshold, the sensitivity and specificity are both about 90%; 







 Use of Erythrocyte Sedimentation Rate and C-Reactive Protein Level to Diagnose Infection Before Revision Total Knee Arthroplasty

Quantitation of c-reactive protein levels and ESR after spinal surgery.   U. Thelander and S. Larsson.  Spine. Vol 17. 1992. p 400-404.

Fever, C-reattive protein, and ESR in monitoring recovery from septic arthritis.  A preliminary study.  H Peltola et al.  J. Pediatric Orthopaedics. Vol 4. 1984. p 170-174.

The usefulness of C-reative protein levels in the identification of concurrent septic arthritis in children who have acute
    hematogenous osteomyelitis: A comparison with the usefulness of the ESR and the white blood cell count.
    L Unkila-Kallio.  JBJS-Am. Vol 76. 1994. p 848-853.

Changes in ESR and C-reactive protein after total hip arthroplasty.     K Aalto et al.  CORR. Vol 184. 1984. p 118-120.

Assessment of the Test Characteristics of C-Reactive Protein for Septic Arthritis in Children.


















Original Text by Clifford R. Wheeless, III, MD.