Cardiac Enzymes


- See: Laboratory Menu

- CPK:
    - normal values:
            - men: less than 174 Units/liter
            - women: less than 140 Units/liter
            - isoenzymes: MM 100%, MB (cardiac) and BB (brain) normally comprise 0%;
    - abnormal values:
            - myocardial infarct
                   - CPK levels begin to rise 4-6 hours after MI has started and reaches its peack values within 30 hrs;
                   - look for an elevation of the CPK MB isoenzymes at 4-6 hours (in MI the CPK MB is more than 5% of total CPK);
            - post surgical elevation: there will be an elevation of the CPK level, but the CPK MB percentage should be close to 0;
            - polymyositis

- Troponin I and T:
    - these are cardiac specific muscle proteins which are elevated with cardiac muscle damage;
    - may also be elevated with pulmonary embolism
    - references:
            - Emergency room triage of patients with acute chest pain by means of rapid testing for cardiac troponin T or troponin I.
            - A proposed strategy for utilization of creatine kinase-MB and troponin I in the evaluation of acute chest pain.



Serum creatine kinase and lactate dehydrogenase changes after anterior approaches to the thoracic and lumbar spine.

Serum CK-MB is useful in diagnosis of acute myocardial infarction after total hip arthroplasty.

Cardiac isoenzyme values after total joint arthroplasty.

Creatine kinase MB in skeletal muscle and serum of spine-fusion patients.

Perioperative creatine phosphokinase (CPK) and troponin I trends after elective hip surgery.

Neuromuscular Symptoms and Elevated Creatine Kinase after Statin Withdrawal

19 Oregon football players treated for rare muscle injury

Aches and Pains Are Worth It




Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Tuesday, September 4, 2012 11:17 am