Orthopaedic Joint Infections: Intra-articular Antibiotics
- properties of antibiotics to cement / properties of vancomycin in cement
- THR infections / - TKR Infections
- septic arthritis
- specific organisms:
- gram negative bacilli: - gram negative cocci: - gram positive bacilli: - gram positive cocci
- Technique and Dosing:
- surgical reimplantation is carried out in the usual manner;
- hickman catheter is tunneled from the joint to the outer skin (catheter cuff is left just beneath the dermis);
- the intra-articular dose of vancomycin is adjusted to meet optimal serum levels;
- initial dose is 500 mg in 10 cc NS infused twice daily;
- be aware that vancomycin can precipitate at high concentrations when mixed with small amounts of cephalosporins and clindamycin;
- human papers:
- A simple method of intra-articular antibiotic delivery in infected hip arthroplasty.
- Direct exchange treatment of septic total joint arthroplasty with intra-articular infusion of antibiotics: technique and early results.
- Methicillin-resistant Staphylococcus aureus in TKA treated with revision and direct intra-articular antibiotic infusion.
- Use of Hickman Catheters for Intraarticular Administration of Antibiotics
- Methicillin-resistant Staphylococcus aureus in TKA Treated With Revision and Direct Intraarticular Antibiotic Infusion
- Two-Stage Exchange for Infected TKA—Opposes
- High-dose antibiotic infusion for infected knee prosthesis without implant removal
- Reinfected Revised TKA Resolves With an Aggressive Protocol and Antibiotic Infusion
- animal papers:
- Intra-articular administration of doxycycline in calves
- Comparison of intraosseous or intravenous infusion for delivery of amikacin sulfate to the tibiotarsal joint of horses
- How to Treat Septic Joints with Constant Intra-articular Infusion of Gentamicin or Amikacin
- Effects of continuous intra-articular infusion of gentamicin on synovial membrane and articular cartilage in the tarsocrural joint of horses.
- Septic Joint Treatment with Constant Intra-articular Infusion of Gentamicin or Amikacin
Original Text by Clifford R. Wheeless, III, MD.
Last updated by Data Trace Staff on Tuesday, November 27, 2012 2:08 pm